MS Wil GmbH

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.. gives your existing Thermo Orbitrap (... & Thermo FTICRs) a quantum boost in data quality and processing sophistication, helping you to add a fresh breeze in performance to your mass spec so that you can unravel your most complex and challenging applications on todays instruments.

related talks at ASMS2017:

 

 

FTMS Booster X1 improves sensitivity, lowers limit of detection and limit of quantitation owing to…

  • Full Transient Recording
  • On-line Absorption Mode FT
  • Full Profile Mode Mass Spectra
  • Reduced Analog and Digital Noise

What is FTMS Booster X1?

FTMS Booster X1 is a high-performance data acquisition and analysis system based on state-of-the-art FPGA (field-programmable gate array) technology. Together with Peak by Peak™ software, FTMS Booster X1 is a complete state-of-the-art solution for acquisition of time-domain signals (transients), real-time digital signal processing, trigger decoding, and off-line data visualization and processing.

Compatible with any Orbitrap™ FTMS platform (LTQ Orbitrap™, Exactive™, and Fusion™ series), FTMS Booster X1 features both on-line and off-line software operation in parallel to installed products. Two complementary data sets are simultaneously and synchronously acquired. Both Booster-produced and conventional transients or mass spectra can be processed by Peak by Peak™ and AutoVectis™ software tools. Booster data is synchronized with metadata produced by the existing software.

FTMS Booster X1 gives your existing instrument a quantum boost in data quality and processing sophistication, helping you to take on the most complex and challenging applications on your instrument.

How does it work ?

High-throughput in-line FPGA technologies are the basis of the new architecture in FTMS Booster X1. Compared to traditional systems, the fidelity, accuracy and extent of the acquired time-domain data are substantially improved. This translates directly into improved analytical performance. 

  • Reduced Noise - which translates to improved sensitivity
  • Dynamic Range
  • Full Transient Recording for Improved Resolution
  • Reduced Phase Distortions for Improved Resolution
  • Mass Accuracy

How is it implemented ?


Parallel, simultaneous acquisition and processing paths maximize instrument and analysis flexibility.

Why is it good for my application ?

The FTMS Booster X1 increases sensitivity, limit of detection (LOD), and limit of quantitation (LOQ) in comparison with standard built-in data acquisition systems for Orbitrap™ FTMS applications, including proteomics. Take a look at sensitivity, LOD, LOQ performance with Orbitrap™ QExactive Plus™ FTMS (Thermo Scientific) with and without FTMS Booster X1.

 

Panel (A) shows a total ion current (TIC) chromatogram, panels (B) and (C) each show mass spectra from LC MS / MS experiment of 6x5 reference peptide mix (Promega). The data are represented in (black) enhanced FT (eFT, Thermo Scientific) and (red) absorption mode FT (aFT, AutoVectis).

 

Imagine you are working on a TMT 10 plex (Tandem Mass Tag™) experiment designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry (MS) e.g. a kit from Thermo. TMT10plex Label Reagents share an identical structure with TMTzero, TMTduplex, and TMTsixplex reagents but contain different numbers and combinations of 13C and 15N isotopes in the mass reporter. Resolving the low mass region and preserving may soon show the limits of todays Orbitrap electronics, as they reduce and fiddle on raw data so that the post processing systems can deal with the data stream.

10 plex TMT using FTMS booster X1   

Blue lines illustrate FTMS Booster X1 compared to original black dotted line generated by Thermos original data processing. It becomes obvious that the resolving power is useful. Experiments probing the effect on TMT ratios show dramatic imrovements as well. Details are explained in ASMS 12016 poster "Implementation of a high-performance FPGA-based data aquisition system for FTMS"


Posters from ASMS 2016:

Boosting FTMS

ASMS 2016 Implementation of a high performance FPGA based data aquasition system for FTMS

Further information as PDF:

Booster for OrbitrapBooster for FTMS

Interested in signing in for a demo or an instrument evaluation ?  Need a quote ??

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