MS Wil GmbH

P.O. Box 1426  - CH 8048 Zurich
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Learn what Surface Acoustic Wave Nebulization (SAWN) can do for you on your API MS 

http://www.deurion.com/ has developed a novel planar method to form ions for mass spectrometry by surface acoustic wave nebulization (SAWN).

Extensive preliminary results have demonstrated several advantages to this method in comparison to electrospray ionization (ESI) and matrix assisted laser desorption (MALDI).

1.: Unlike ESI, a high voltage electric field is not required eliminating the chance of redox reactions occurring.

2.: There are no capillaries to be clogged and the planar geometry of the SAWN platform allows for the integration of complex fluid handling by droplet-based microfluidics (DMF) 

3.:  Analysis with thermometer ions has shown that SAWN is softer (i.e. less fragmentation occurs) than both ESI and MALDI.

 The implementation can be conducted on MS systems from vendors such as Waters, Thermo, Sciex..

 Swan on Waters G2 Z-spray interface  SWAN on Sciex Triple ToF

 The SAWN interface is controlled by a control box & an android tablet computer as shown below

 

For more information please visit http://www.deurion.com/ 

For instrument demos on your mass spec please contact This email address is being protected from spambots. You need JavaScript enabled to view it.

 


SAWN References

  • Astefanei et al. Surface acoustic wave nebulisation-mass spectrometry (SAWN-MS) for the fast and highly sensitive characterisation of synthetic dyes in textile samples. J Am Soc Mass Spectrom. 2017 in press.
  • Scheinder et al. Mass Spectrometry for Rapid Analysis of Food Products Using Surface Acoustic Wave Nebulization. 2017 in preparation.
  • Huang et al. Surface acoustic wave nebulization device with dual interdigitated transducers improves SAWN-MS performance. J Mass Spectrom. 2016 Jun;51(6):424-9.
  • Monkkonen et al. Screen-printed digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements. J Chromatogr A. 2016 Mar 25;1439:161-6.
  • Hommersom et al. An ambient detection system for visualization of charged particles generated with ionization methods at atmospheric pressure. Rapid Commun Mass Spectrom. 2016 Feb 15;30(3):352-8.
  • Yoon et al. Surface acoustic wave nebulization facilitating lipid mass spectrometric analysis. Anal Chem. 2012 Aug 7;84(15):6530-7.
  • Huang et al. Surface acoustic wave nebulization produces ions with lower internal energy than electrospray ionization. J Am Soc Mass Spectrom. 2012 Jun;23(6):1062-70.
  • Heron et al. Surface acoustic wave nebulization of peptides as a microfluidic interface for mass spectrometry. Anal Chem. 2010 May 15;82(10):3985-9.