MagReSyn ZrO2 (2 ml)
The highly-specific capture of phosphorylated peptides from complex protein digests pose a significant challenge to proteomics researchers. Several technologies with varying degrees of specificity and affinity have been developed to enrich phosphopeptides. These different technologies can be used either alone or in combination to increase coverage of the phosphoproteome. MagReSyn® ZrO2 microparticles allow highly specific, reproducible enrichment of phosphopeptides from complex biological samples such as protein digests. MagReSyn® ZrO2 microparticles may be used alone or in combination with MagReSyn® TiO2, MagReSyn® Zr-IMAC and/or MagReSyn® Ti-IMAC microparticles to enrich diverse types of phosphopeptides for comprehensive phosphproteomics analyses. Products for phosphopeptide enrichment are validated for the intended application using our stringent QC procedures.

MagReSyn Technology Description

New miniaturized, high throughput technologies for bioseparation, diagnostics, DNA sequencing, flow cytometry, drug discovery, proteomics and genomics are in many instances reliant on attachment of functional biological molecules to a microsphere support. The vast array of life sciences applications include: capture reagents for immunoassay (fluorescence, enzyme linked etc); surfaces for immunoprecipitation; diagnostic assays; fluorescence microscopy; flow/imaging cytometry; magnetic cell separation; molecular diagnostics; agglutination tests; nucleic acid separation and protein separation among others.

Conventional microparticle technologies use solid or porous/cracked microparticles with binding of biological molecules limited to the surface, a key factor constraining performance and the development of new applications for microparticle technologies and products. We have developed a novel (patented) microparticle technology platform, comprising a hyper-porous polymer matrix that allows penetration of biological and synthetic molecules throughout the volume of the microparticles. This offers exceptionally high surface area for binding of molecules and allows performance that is orders of magnitude greater than alternate technologies. The binding capacity serves as a major performance contributor to the number of applications and versatility for end-user applications by and further enables miniaturization, increased sensitivity and reducing the cost of R&D.