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Recently, the Journal of Pharmaceutical and Biomedical Analysis published research from the team at Regeneron that included Newomics innovative multinozzle M3 emitter and their MnESI source, to achieve nanospray native MS for studying antibody affinity binding. Newomics MnESI source empowers the M3 emitter to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for LC/MS analysis. The M3 emitter, unlike the conventional single-tip emitters, has multiple nozzles working together to split a single large flow stream evenly into multiple tiny flows, the way a showerhead works. The MnESI source is designed to simplify the user experience by enabling…

It is well known that nano/micro flow chromatography columns are best placed close to the orifice of your mass spectrometer to avoid any post-column dead volumes causing peak broadening. It is also well known that temperature control will, not only reduce back pressure, but also increase reproducibility of your chromatographic experiment. When using Thermo Scientific™ Orbitrap™ or Quadrupole based mass spectrometers there is a choice of two types of Ion Sources suitable for nanoSpray applications, namely the Nanospray Flex™ Series and EASY-Spray™ model. With products from Phoenix S&T (PST), MS Wil developed a kit to fit your columns seamlessly on one…

Many Thermo Scientific customers have been trained to use the magnetic coupler on the end of the DirectJunction™ column rail (nanoSpray Flex™ ion source) to connect a fused silica emitter with a coated tip, in order to apply voltage to enable electrospray. Others use distal-coated tips in which the coating is used to apply voltage at the entry of the emitter. With a global shortage in the supply of coated emitters, our customers have no choice than to change their emitter set-up slightly. We have found that there are basically three ways forward (which we will elaborate on in this…

Since it is our goal to be a one-stop-shop for fine Mass Spectrometry Tools, we are constantly searching for new products to extend our portfolio. Even during the Summer Holidays we have been busy looking for new solutions to optimize your research, and help Make your Science Work. Therefore, we would like to present to you an overview of our new products: Aurora UHPLC Columns IonOpticks produces high-performance nanoflow chromatography solutions, including their high-performance and user-friendly Aurora UHPLC Columns. Delivering unrivalled coverage, throughput, sensitivity and reproducibility, Generation 3 Aurora SeriesTM columns embody all of the strengths of previous generations, augmented by…