MSWIL location

MS Wil B.V.
Bosscheweg 60A
5735GW Aarle-Rixtel
the Netherlands

P: +31492745710       
F: +31492745719      
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Learn how  PharmaFluidics µPACTM cartridges overcome peak dispersion challanges of traditional packed fused silica columns with their proprietary flow distribution structures, resulting in less sample preparation, higher throughput and an unprecedented analytical result. 

Careful etching away the interstitial volumes out of a silicon wafer support leaves an array of pillars. This creates a stationary phase support structure that is organized in a reproducible, perfectly ordered pattern. The perfect order of the etched bed eliminates peak dispersion introduced by otherwise heterogeneous (eddy) flows in disordered/packed beds, creating much higher plate counts and sharper peaks. Consequently, samples are diluted less during elution, increasing sensitivity.

Intrinsically free-standing, the pillar support structures allow flow with minimal back-pressure build up. As there are no obstructions by touching surfaces of the stationary phase, blocking the regular flow of the mobile phase, µPACsTM return low back-pressures at high flow rates. 

With the separation bed being fixed to its silicon support, µPACTM cartridges can also be used in reverse flow mode. This is a handy feature, enabling back flush for column cleaning. Columns of unprecedented length (50 & 200 cm) are created on a small footprint. This is achieved by interconnecting several separation lanes by means of proprietary turn structures. Carefully engineered flow distributors allow to make these turns with no additional peak dispersion. The resulting long columns give the sample more time to interact with the stationary phase, leading to unmatched separation power. 



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Technote part 1      Technote part 2 

Application Example on Thermo Lumos      mAb peptide mapping HUPO 2017


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