Build for Superior Microflow and Nanoflow LC-MS
DuoESI Platform = DuoESI Source + M3 Emitter
The DuoESI source empowers the Newomics award-winning M3 multi-nozzle emitter, and MEA chip with a column monolithically integrated with a multinozzle emitter on a chip, to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for multiomics analysis.
Its swappable microflow and nanoflow modules deliver two ion sources (nano/micro) in one, reducing sample preparation and SOPs. It is compatible with mass spectrometers from five of the world’s leading mass spec vendors. The DuoESI-MS Source is also compatible with IonOpticks’ TS Heated Columns.
Features & Benefits:
- The first interchangeable microflow and nanoflow ion source by a simple swap
- Compatible with all mass spectrometers from Thermo, Bruker, Agilent, and Shimadzu
- Plug-and-play platform for nanoflow and microflow MEA chips
- Plug-and-play platform for M3 emitters
- Plug-and-play platform for IonOpticks’ TS Heated Columns
- Receive two ion sources for the price of one
DuoESI Platform Specifications
| Parameter | Specifications |
| Ionization Mode | Atmospheric pressure electrospray ionization (ESI), both positive and negative mode. |
| ESI Probe | Newomics M3 Emitter |
| Open or Closed System | Semi-closed source |
| Flow Rate | Nano (20 – 1000 nL/min), for nanoMEA chips Micro (1 – 50 µL/min), for M3 emitters and microMEA chips |
| Spray Angle | Fixed angle of 25° for emitters 0° angle for nanoMEA chips |
| Capillary Voltage | 0 – 6 kV |
| Spray Current | 0 – 10 µA, max. 40µA |
| Sheath Gas Flow Setting | 0 – 30 (arbitrary units) |
| N2 Nebulizer Gas Flow Setting | 0 – 60 psi |
| Auxiliary Gas Flow Setting | 0 – 20 (arbitrary units, optional) |
| Translational Stage | Linear XY-axis manual stage, ±5mm travel distance, 30µm travel accuracy |
| Camera | 1.3M pixels, 20x – 90x magnification rate, color CMOS sensor, up to 30 fps frame rate |
| Light Source | Cool white (9000K) 5mm round LED light, luminous intensity 46400 mcd |
| Connection | Face seal, finger-tight 10-32 threaded fittings including Thermo nanoViper, IDEX MarvelX and MarvelXACT, Waters ZenFit, Phenomenex SecurityLink, VICI Cheminert C360IZR1, and nanoConnect. |
| Unit Dimension | Width: 25 cm (9.8 in.) Height: 17.5 cm (6.9 in.) Depth: 15 cm (5.9 in.) |
| Unit Weight | 3kg (6.6 lbs) |
Models and MS Compatibility
IS-A01D
DuoESI Source for Agilent Mass Spectrometers. Compatible with: 6500 Series Q-TOF, 6400 Series QQQ, 6200 Series TOF, and all other Agilent Mass Spectrometers.
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IS-B01D
DuoESI Source for Bruker Mass Spectrometers. Compatible with: timsTOF series (timsTOF Pro, timsTOF Pro2, timsTOF SCP, timsTOF flex), Compact, impact II, and maxis II QTOF MS, maXisTOF flex MALDI-2 MS (ESI side), solariX and scimaX MRMS; amazon Ion Trap MS.
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IS-T01D
DuoESI Source for Thermo Scientific New Generation Mass Spectrometers. Compatible with: Orbitrap Exploris (120, 240, 480), Orbitrap Tribrid Series (Fusion, Lumos, ID-X, Eclipse, Ascend), TSQ Series II (Endura, Quantiva, Altis, Quantis, Fortis).
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IS-T02D
DuoESI Source for Thermo Scientific Legacy Mass Spectrometers. Compatible with: Q Exactive Series (QE Focus, QE, QE Plus, QE HF, QE HFX, QE UHMR), Exactive Series (Exactive Plus, Exactive Plus EMR), Orbitrap Eite LTQ Series (LTQ XL, LTQ Orbitrap XL, Velos Pro), LCQ Fleet TSQ Series (Quantum, Vantage).
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